![]() Large-scale genome-wide association studies, principally in European-derived whites and in Chinese, have discovered approximately 50 different genetic loci that contribute to vitiligo risk, some of which also contribute to other autoimmune diseases that are epidemiologically associated with vitiligo. Synopsis Vitiligo is “complex disorder†(also termed polygenic and multifactorial), reflecting simultaneous contributions of multiple genetic risk factors and environmental triggers. CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck. Some limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results. ![]() As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area. Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Of the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The maximum follow-up period for some patients was 24 months. Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Ramos, Mariana Gontijo Ramos, Daniel Gontijo Ramos, Camila Gontijo PMID:21911918Įvaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo. We also discuss the implications of our recent findings for the interpretation of patient responses, and the design of next-generation cancer immunotherapies. This research perspective reviews the history of melanoma-associated vitiligo in patients, the experimental studies that form the basis for understanding this relationship, and the unique characteristics of melanoma-specific CD8 T cells found in hosts with vitiligo. ![]() However, new data reveal a key role for vitiligo in supporting T cell responses to melanoma. Although vitiligo is an independent positive prognostic factor for melanoma patients, the autoimmune destruction of melanocytes was long thought to be merely a side effect of robust anti-tumor immunity. Melanoma-associated vitiligo is the best-studied example of the linkage between tumor immunity and autoimmunity. New Perspectives on the Role of Vitiligo in Immune Responses to Melanoma This is also a rare case in which 90% repigmentation was achieved in patient with segmental and nonsegmental vitiligo following Blaschko lines in only 2 months of combined therapy. ![]() Prior to our report, a case of segmental and non-segmental vitiligo followed by Blaschko lines was never described, therefore we suggest the term "mixed vitiligo of Blaschko lines" to describe this entity. Here, we present patient with segmental and non-segmental vitiligo following Blaschko lines with excellent therapeutic response to combined therapy. Segmental vitiligo can also follow Blaschko lines - pathways of epidermal cell migration and proliferation during the development of the fetus. Non-segmental vitiligo refers to non-dermatomal distribution of lesions, while dermatomal distribution of lesions is present in patients with segmental vitiligo. It is classified into four major types: segmental, non-segmental, mixed, and unclassified type. Vitiligo, depigmenting disorder of the skin and mucous membranes, affects up to 1% of the population worldwide. Kovacevic, Maja Stanimirovic, Andrija Vucic, Majda Goren, Andy Situm, Mirna Lukinovic Skudar, Vesna Lotti, Torello Mixed vitiligo of Blaschko lines: a newly discovered presentation of vitiligo responsive to combination treatment.
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